Extensive Translational Regulation through the Proliferative Transition of Trypanosoma cruzi Revealed by Multi-Omics-Reference-Cited by-同舟云学术

Extensive Translational Regulation through the Proliferative Transition of Trypanosoma cruzi Revealed by Multi-Omics

Published:2021-10-27 Issue:5 Volume:6 Page:
ISSN:2379-5042
Container-title:mSphere
language:en
Short-container-title:mSphere

Author:

Chávez Santiago¹²³^ORCID,Urbaniak Michael D.⁴,Benz Corinna⁴,Smircich Pablo¹²,Garat Beatriz¹,Sotelo-Silveira José R.³⁵,Duhagon María Ana¹²^ORCID

Affiliation:

1. Laboratorio de Interacciones Moleculares, Facultad de Ciencias, Universidad de la República, Montevideo, Uruguay

2. Departamento de Genética, Facultad de Medicina, Universidad de la República, Montevideo, Uruguay

3. Departamento de Genómica, Instituto de Investigaciones Biológicas Clemente Estable, Ministerio de Educación y Cultura, Montevideo, Uruguay

4. Biomedical and Life Sciences, Faculty of Health and Medicine, Lancaster University, Lancaster, United Kingdom

5. Departamento de Biología Celular y Molecular, Facultad de Ciencias, Universidad de la República, Montevideo, Uruguay

Abstract

Trypanosoma cruzi is an ancient eukaryotic unicellular parasite causing Chagas disease, a potentially life-threatening illness that affects 6 to 7 million people, mostly in Latin America. The antiparasitic treatments for the disease have incomplete efficacy and adverse reactions; thus, improved drugs are needed.

Funder

PEDECIBA Biologica, MEC

UdelaR | Comisión Sectorial de Investigación Científica

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mSphere.00366-21

Reference85 articles.

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2. The trypanosomiases

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5. Transcriptional regulation and function during the human cell cycle

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