Severity of arthritis is predicted by antibody response to gp135 in chronic infection with caprine arthritis-encephalitis virus

Author:

Knowles D1,Cheevers W1,McGuire T1,Stem T1,Gorham J1

Affiliation:

1. Animal Disease Research Unit, U.S. Department of Agriculture-Agricultural Research Service, Pullman, Washington 99164-7030.

Abstract

Antibody titers to caprine arthritis-encephalitis virus surface glycoprotein gp135 and core protein p28 in synovial fluid and serum from 35 goats infected for 3 years were compared with the histologic severity of arthritis in these animals. Anti-gp135 antibody titers in synovial fluid and serum directly reflect the severity of carpal arthritis in chronically infected goats.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Reference15 articles.

1. A pathogenetic study of the early connective tissue lesions of viral caprine arthritis-encephalitis;Adams D. S.;Am. J. Pathol.,1980

2. Bruning J. L. and B. L. Kintz. 1968. Nonparametric tests miscellaneous tests of significance and indices of relationship p. 195-215. In J. L. Bruning and B. L. Kintz (ed.) Computational handbook of statistics 1st ed. Scott Foresman and Co. Atlanta.

3. Chronic disease in goats orally infected with two isolates of the caprine arthritisencephalitis lentivirus;Cheevers W. P.;Lab. Invest.,1988

4. Precursor polypeptides of caprine arthritis-encephalitis lentivirus structural proteins;Cheevers W. P.;J. Gen. Virol.,1988

5. Biochemical characterization of the virus causing leukoencephalitis and arthritis in goats;Clements J. E.;J. Gen. Virol.,1980

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