Virulent Brucella abortus Prevents Lysosome Fusion and Is Distributed within Autophagosome-Like Compartments-Reference-Cited by-同舟云学术

Virulent Brucella abortus Prevents Lysosome Fusion and Is Distributed within Autophagosome-Like Compartments

Published:1998-05 Issue:5 Volume:66 Page:2387-2392
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Pizarro-Cerdá Javier¹,Moreno Edgardo¹,Sanguedolce Veronique²,Mege Jean-Louis²,Gorvel Jean-Pierre¹

Affiliation:

1. Centre d’Immunologie INSERM-CNRS de Marseille-Luminy, 13288 Marseille Cedex 9,1 and

2. Centre National de Référence des Rickettsioses, Centre Hospitalier Universitaire la Timone, 13385 Marseille,2 France

Abstract

ABSTRACT Virulent and attenuated Brucella abortus strains attach to and penetrate nonprofessional phagocytic HeLa cells. Compared to pathogenic Brucella , the attenuated strain 19 hardly replicates within cells. The majority of the strain 19 bacteria colocalized with the lysosome marker cathepsin D, suggesting that Brucella -containing phagosomes had fused with lysosomes, in which they may have degraded. The virulent bacteria prevented lysosome-phagosome fusion and were found distributed in the perinuclear region within compartments resembling autophagosomes.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.66.5.2387-2392.1998

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