Proteins Encoded by the cag Pathogenicity Island of Helicobacter pylori Are Required for NF-κB Activation-Reference-Cited by-同舟云学术

Proteins Encoded by the cag Pathogenicity Island of Helicobacter pylori Are Required for NF-κB Activation

Published:1998-05 Issue:5 Volume:66 Page:2346-2348
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Glocker Erik¹²,Lange Christina³,Covacci Antonello³,Bereswill Stefan²,Kist Manfred²,Pahl Heike L.¹

Affiliation:

1. Institute for Experimental Cancer Research, Tumor Biology Center, D-79106 Freiburg,1 and

2. Institut für Medizinische Mikrobiologie und Hygiene, Universität Freiburg, 79104 Freiburg,2Germany, and

3. IRIS-BIOCINE, 53100 Siena, Italy3

Abstract

ABSTRACT Helicobacter pylori is the etiological agent in the development of chronic gastritis, duodenal ulceration, and gastric adenocarcinoma. The difference in virulence between individual strains is reflected in their ability to induce interleukin-8 (IL-8) secretion from gastric epithelial cells. It has been shown that virulence is associated with the presence of a bacterial gene cluster (a pathogenicity island). We have recently demonstrated that H. pylori -mediated IL-8 secretion requires activation of the transcription factor NF-κB. Here, we show that NF-κB induction requires six membrane proteins encoded within the pathogenicity island.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.66.5.2346-2348.1998

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