Pseudomonas aeruginosa Pyocyanin Is Critical for Lung Infection in Mice-Reference-Cited by-同舟云学术

Pseudomonas aeruginosa Pyocyanin Is Critical for Lung Infection in Mice

Published:2004-07 Issue:7 Volume:72 Page:4275-4278
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Lau Gee W.¹,Ran Huimin¹,Kong Fansheng¹,Hassett Daniel J.²,Mavrodi Dimitri³

Affiliation:

1. Division of Pulmonary and Critical Care Medicine

2. Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267-0564

3. Department of Plant Pathology, Agricultural Research Service, Washington State University, Pullman, Washington 99164-6430

Abstract

ABSTRACT Pseudomonas aeruginosa secretes copious amounts of the redox-active phenazine, pyocyanin (PCN), during cystic fibrosis lung infection. PCN has been shown to interfere with a variety of cellular processes in cultured lung epithelial cells. Here, by using two respiratory tract models of infection, we demonstrate that PCN mediates tissue damage and necrosis during lung infection.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.72.7.4275-4278.2004

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