Affiliation:
1. Department of Medical Microbiology, City Hospital Trust, Birmingham, United Kingdom.
Abstract
GV104326 is a novel tricyclic beta-lactam (a trinem or, formerly, tribactam). The in vitro activity of GV104326 was compared with those of cefuroxime, cefixime, amoxicillin, amoxicillin-clavulanic acid, cefpirome, and ciprofloxacin. GV104326 had in vitro activity generally similar to that of cefixime against members of the family Enterobacteriaceae (MIC at which 90% of the isolates are inhibited [MIC90], < or = 2 micrograms/ml), with cefuroxime and amoxicillin-clavulanic acid being 8- to 32-fold less active and with cefpirome being 4- to 8-fold more active against members of this family. The trinem had no activity against Pseudomonas aeruginosa or Stenotrophomonas maltophilia (MIC90, > 128 micrograms/ml) but was the most active agent against Acinetobacter calcoaceticus. GV104326 was particularly active against gram-positive cocci. Ninety percent of methicillin-susceptible Staphylococcus aureus strains were susceptible to 0.03 microgram of GV104326 per ml, making it the most active agent studied. Enterococci and Lancefield group A and B streptococci were generally equally or somewhat more susceptible to GV104326 than they were to amoxicillin. Streptococcus pneumoniae strains were highly susceptible to GV104326, and those strains which showed decreased susceptibility to penicillin were generally twofold more susceptible to the trinem than to amoxicillin. Haemophilus influenzae and Moraxella catarrhalis were highly susceptible to GV104326 (MIC90s, 0.12 and 0.03 microgram/ml, respectively). The anaerobes Clostridium perfringens, Bacteroides fragilis, and Peptostreptococcus spp. were more susceptible to the trinems (formerly tribactams) than to the other agents studied.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
Reference8 articles.
1. A functional classification scheme for ~-lactamases and its correlation with molecular structure;Bush K.;Antimicrob. Agents Chemother.,1995
2. In vitro activity of the tribactam GV104326 against gram-positive, gram-negative, and anaerobic bacteria;Di Modugno E.;Antimicrob. Agents Chemother.,1994
3. Efthymiopoulos C. A. Capriati P. Barrington J. Patel E. V. B. Shenoy and A. Bye. 1994. Pharmacokinetics of GV104326 a novel tribactam antibiotic following single intravenous and oral (as its prodrug GV118819X) administration in man abstr. F82 p. 129. In Program and abstracts of the 34th Interscience Conference on Antimicrobial Agents and Chemotherapy. American Society for Microbiology Washington D.C.
4. National Committee for Clinical Laboratory Standards. 1994. Antimicrobial susceptibility testing. SC3. National Committee for Clinical Laboratory Standards Villanova Pa.
5. O'Brien T. F. and the International Survey of Antibiotic Resistance Group. 1986. Resistance to antibiotics at medical centres in different parts of the world. J. Antimicrob. Chemother. 18(Suppl. C):243-253.
Cited by
23 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献