Characterization of Pyrin Dephosphorylation and Inflammasome Activation in Macrophages as Triggered by the Yersinia Effectors YopE and YopT-Reference-Cited by-同舟云学术

Characterization of Pyrin Dephosphorylation and Inflammasome Activation in Macrophages as Triggered by the Yersinia Effectors YopE and YopT

Published:2019-03 Issue:3 Volume:87 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Medici Natasha P.¹,Rashid Maheen¹,Bliska James B.¹²^ORCID

Affiliation:

1. Department of Molecular Genetics and Microbiology, Center for Infectious Diseases, Stony Brook University, Stony Brook, New York, USA

2. Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Dartmouth College, Hanover, New Hampshire, USA

Abstract

Pathogenic Yersinia species deliver Yop effector proteins through a type III secretion system into host cells. Among these effectors, YopE and YopT are Rho-modifying toxins, which function to modulate host cell physiology and evade immune responses.

Funder

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior

HHS | NIH | National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.00822-18

Reference41 articles.

1. Bacterial Toxins as Pathogen Weapons Against Phagocytes

2. General Aspects and Recent Advances on Bacterial Protein Toxins

3. Functional domains and motifs of bacterial type III effector proteins and their roles in infection

4. Rho-modifying bacterial protein toxins

5. Guanine nucleotide exchange factors for Rho GTPases: turning on the switch

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