A Multicenter Study To Evaluate Ceftaroline Breakpoints: Performance in an Area with High Prevalence of Methicillin-Resistant Staphylococcus aureus Sequence Type 5 Lineage-Reference-Cited by-同舟云学术

A Multicenter Study To Evaluate Ceftaroline Breakpoints: Performance in an Area with High Prevalence of Methicillin-Resistant Staphylococcus aureus Sequence Type 5 Lineage

Published:2019-09 Issue:9 Volume:57 Page:
ISSN:0095-1137
Container-title:Journal of Clinical Microbiology
language:en
Short-container-title:J Clin Microbiol

Author:

Khan Ayesha¹²³^ORCID,Rivas Lina M.⁴⁵,Spencer Maria⁴⁵,Martinez Rodrigo⁴⁵,Lam Marusella⁶,Rojas Pamela⁷,Porte Lorena⁴⁵,Silva Francisco⁸,Braun Stephanie⁹,Valdivieso Francisca¹⁰,Mv̈lhauser Margareta¹¹,Lafourcade Mónica¹²,Miller William R.¹,García Patricia⁵⁶,Arias Cesar A.¹²⁵¹³¹⁴,Munita Jose M.¹⁴⁵

Affiliation:

1. Center for Antimicrobial Resistance and Microbial Genomics and Division of Infectious Diseases, University of Texas Health Science Center, McGovern Medical School, Houston, Texas, USA

2. Department of Microbiology and Molecular Genetics, University of Texas Health Science Center, McGovern Medical School, Houston, Texas, USA

3. MD Anderson Cancer Center, UT Health Graduate School of Biomedical Sciences, Houston, Texas, USA

4. Genomics and Resistant Microbes Group, Facultad de Medicina-Clinica Alemana, Universidad del Desarrollo, Santiago, Chile

5. Millennium Initiative for Collaborative Research on Bacterial Resistance (MICROB-R), Millennium Science Initiative, Santiago, Chile

6. Departamento de Laboratorios Clínicos, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile

7. Hospital Padre Hurtado, Santiago, Chile

8. Hospital Clínico Universidad de Chile, Santiago, Chile

9. Hospital Militar, Santiago, Chile

10. Hospital Dr. Luis Calvo Mackenna, Santiago, Chile

11. Hospital Dipreca, Santiago, Chile

12. Clínica Santa María, Santiago, Chile

13. Molecular Genetics and Antimicrobial Resistance Unit, International Center for Microbial Genomics, Universidad El Bosque, Bogotá, Colombia

14. Center for Infectious Diseases, University of Texas Health Science Center, School of Public Health, Houston, Texas, USA

Abstract

Ceftaroline (CPT) is a broad-spectrum agent with potent activity against methicillin-resistant Staphylococcus aureus (MRSA). The sequence type 5 (ST5) Chilean-Cordobés clone, associated with CPT nonsusceptibility, is dominant in Chile, a region with high rates of MRSA infections.

Funder

Comision Nacional de Investigacion Cientifica y Tecnologica

Millenium Science Initiative of the Ministry of Economy, Development and Tourism, Government of Chile

HHS | NIH | National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Link

https://journals.asm.org/doi/pdf/10.1128/JCM.00798-19

Reference32 articles.

1. Staphylococcus aureusBacteremia: Epidemiology, Pathophysiology, and Management Strategies