Novel Insights into the Classification of Staphylococcal β-Lactamases in Relation to the Cefazolin Inoculum Effect-Reference-Cited by-同舟云学术

Novel Insights into the Classification of Staphylococcal β-Lactamases in Relation to the Cefazolin Inoculum Effect

Published:2020-04-21 Issue:5 Volume:64 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Carvajal Lina P.¹,Rincon Sandra¹,Echeverri Aura M.¹,Porras Jessica¹,Rios Rafael¹,Ordoñez Karen M.²,Seas Carlos³,Gomez-Villegas Sara I.⁴,Diaz Lorena¹,Arias Cesar A.¹⁴⁵⁶⁷,Reyes Jinnethe¹

Affiliation:

1. Molecular Genetics and Antimicrobial Resistance Unit, International Center for Microbial Genomics, Universidad El Bosque, Bogota, Colombia

2. E.S.E. Hospital Universitario San Jorge de Pereira, Risaralda, Colombia

3. Hospital Cayetano Heredia, Instituto de Medicina Tropical Alexander von Humboldt, Universidad Peruana Cayetano Heredia, Lima, Peru

4. Center for Antimicrobial Resistance and Microbial Genomics, McGovern Medical School, University of Texas Health Science Center, Houston, Texas, USA

5. Division of Infectious Diseases, Department of Internal Medicine, McGovern Medical School, University of Texas Health Science Center, Houston, Texas, USA

6. Department of Microbiology and Molecular Genetics, McGovern Medical School, University of Texas Health Science Center, Houston, Texas, USA

7. Center for Infectious Diseases, School of Public Health, McGovern Medical School, University of Texas Health Science Center, Houston, Texas, USA

Abstract

Cefazolin has become a prominent therapy for methicillin-susceptible Staphylococcus aureus (MSSA) infections. However, an important concern is the cefazolin inoculum effect (CzIE), a phenomenon mediated by staphylococcal β-lactamases. Four variants of staphylococcal β-lactamases have been described based on serological methodologies and limited sequence information. Here, we sought to reassess the classification of staphylococcal β-lactamases and their correlation with the CzIE.

Funder

HHS | National Institutes of Health

Departamento Administrativo de Ciencia, Tecnología e Innovación

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.02511-19

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