Genomic Analysis Reveals Antibiotic-Susceptible Clones and Emerging Resistance in Neisseria gonorrhoeae in Saskatchewan, Canada-Reference-Cited by-同舟云学术

Genomic Analysis Reveals Antibiotic-Susceptible Clones and Emerging Resistance in Neisseria gonorrhoeae in Saskatchewan, Canada

Published:2020-08-20 Issue:9 Volume:64 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Parmar Nidhi R.¹²^ORCID,Singh Reema¹²,Martin Irene³,Perera Sumudu R.¹²,Demczuk Walter³,Kusalik Anthony⁴,Minion Jessica⁵,Dillon Jo-Anne R.¹²^ORCID

Affiliation:

1. Department of Biochemistry, Microbiology and Immunology, University of Saskatchewan, Saskatoon, Saskatchewan, Canada

2. Vaccine and Infectious Disease Organization—International Vaccine Centre, University of Saskatchewan, Saskatoon, Saskatchewan, Canada

3. Bacterial Pathogen Division, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada

4. Department of Computer Science, University of Saskatchewan, Saskatoon, Saskatchewan, Canada

5. Roy Romanow Provincial Laboratory, Regina, Saskatchewan, Canada

Abstract

Whole-genome sequencing was used to identify mutations in antibiotic resistance-conferring genes to compare susceptibility predictions with MICs and to ascertain strain types in 99 isolates of Neisseria gonorrhoeae . Genotypes associated with susceptibility, as well as MIC creep or emerging resistance, were noted. Phylogenomic analysis revealed three distinctive clades and putative gonococcal transmission linkages involving a tetracycline-resistant N. gonorrhoeae outbreak and the clonal spread of susceptible isolates in men.

Funder

Gouvernement du Canada | Natural Sciences and Engineering Research Council of Canada

Gouvernement du Canada | Canadian Institutes of Health Research

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.02514-19

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