Structural Basis for Rabbit Hemorrhagic Disease Virus Antibody Specificity

Author:

Leuthold Mila M.123ORCID,Kilic Turgay23,Devant Jessica M.23,Landeta Oscar4,Parra Francisco5,Dalton Kevin P.5,Hansman Grant S.236ORCID

Affiliation:

1. Medicinal Chemistry, Institute of Pharmacy and Molecular Biotechnology, University of Heidelberg, Heidelberg, Germany

2. Schaller Research Group at the University of Heidelberg and the DKFZ, Heidelberg, Germany

3. Department of Infectious Diseases, Virology, University of Heidelberg, Heidelberg, Germany

4. Certest Biotec, Pol Industrial Rio Gallego II, San Mateo de Gallego, Zaragoza, Spain

5. Instituto Universitario de Biotecnología de Asturias, Departamento de Bioquímica y Biología Molecular, Edificio Santiago Gascón, Universidad de Oviedo, Oviedo, Spain

6. Institute for Glycomics, Griffith University, Gold coast, Australia

Abstract

Isolated RHDV antibodies have been used for decades to distinguish between antigenic variants, monitor temporal capsid evolution, and examine neutralizing capacities. In this study, we provided the structural basis for an RHDV GI.2 specific diagnostic antibody (2D9) binding and reveal that a small number of amino acid substitutions at the binding site could differentiate between RHDV GI.2 and GI.1b.

Funder

Deutsche Forschungsgemeinschaft

Spanish Ministerio de Economía y Competitividad, cofinanced by FEDER

Principado de Asturias

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

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