Pyrazinoic Acid Decreases the Proton Motive Force, Respiratory ATP Synthesis Activity, and Cellular ATP Levels-Reference-Cited by-同舟云学术

Pyrazinoic Acid Decreases the Proton Motive Force, Respiratory ATP Synthesis Activity, and Cellular ATP Levels

Published:2011-11 Issue:11 Volume:55 Page:5354-5357
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Lu Ping¹²,Haagsma Anna C.¹²,Pham Hoang¹,Maaskant Janneke J.³,Mol Selena¹²,Lill Holger¹²,Bald Dirk¹²

Affiliation:

1. Department of Molecular Cell Biology, Earth and Life Sciences, VU University Amsterdam, De Boelelaan 1085, 1081 HV Amsterdam, The Netherlands

2. Amsterdam Institute for Molecules, Medicines and Systems (AIMMS), Amsterdam, The Netherlands

3. Department of Medical Microbiology and Infection Control, VU University Medical Center, Amsterdam, The Netherlands

Abstract

ABSTRACT Pyrazinoic acid, the active form of the first-line antituberculosis drug pyrazinamide, decreased the proton motive force and respiratory ATP synthesis rates in subcellular mycobacterial membrane assays. Pyrazinoic acid also significantly lowered cellular ATP levels in Mycobacterium bovis BCG. These results indicate that the predominant mechanism of killing by this drug may operate by depletion of cellular ATP reserves.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00507-11

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