In Vitro Susceptibilities of 400 Spanish Isolates of Neisseria gonorrhoeae to Gemifloxacin and 11 Other Antimicrobial Agents-Reference-Cited by-同舟云学术

In Vitro Susceptibilities of 400 Spanish Isolates of Neisseria gonorrhoeae to Gemifloxacin and 11 Other Antimicrobial Agents

Published:2000-09 Issue:9 Volume:44 Page:2543-2544
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Berrón S.¹,Vázquez J. A.¹,Giménez M. J.²,de la Fuente L.¹,Aguilar L.²

Affiliation:

1. Spanish National Reference Laboratory for Gonococci, Instituto de Salud Carlos III, 28220 Majadahonda, Madrid,1 and

2. SmithKline Beecham Pharmaceuticals, 28034 Madrid,2 Spain

Abstract

ABSTRACT The in vitro activity of gemifloxacin versus those of 11 other antimicrobial agents against 400 strains of Neisseria gonorrhoeae was determined by microdilution with supplemented GC agar. A total of 37.5% of the strains were β-lactamase positive. A total of 70 and 6.4% of the β-lactamase-negative strains exhibited intermediate and high-level penicillin resistance, respectively. Ceftriaxone and gemifloxacin were the most active drugs (MICs at which 90% of isolates are inhibited, 0.01 versus 0.007 μg/ml, respectively), with 100% of strains inhibited by 0.12 μg/ml.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.44.9.2543-2544.2000

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