Cryptococcal Meningitis Diagnostics and Screening in the Era of Point-of-Care Laboratory Testing-Reference-Cited by-同舟云学术

Cryptococcal Meningitis Diagnostics and Screening in the Era of Point-of-Care Laboratory Testing

Published:2019-01 Issue:1 Volume:57 Page:
ISSN:0095-1137
Container-title:Journal of Clinical Microbiology
language:en
Short-container-title:J Clin Microbiol

Author:

Rajasingham Radha¹,Wake Rachel M.²³,Beyene Tafese⁴,Katende Andrew⁵,Letang Emilio⁵⁶⁷⁸⁹,Boulware David R.¹

Affiliation:

1. Division of Infectious Diseases and International Medicine, University of Minnesota, Minneapolis, Minnesota, USA

2. Centre for Healthcare-Associated Infections, Antimicrobial Resistance and Mycoses, National Institute for Communicable Diseases, Johanneseburg, South Africa

3. Institute for Infection and Immunity, St George’s University of London, London, United Kingdom

4. Asella Teaching Hospital, College of Health Sciences, Arsi University, Asella, Ethiopia

5. Ifakara Health Institute, Ifakara, United Republic of Tanzania

6. Swiss Tropical and Public Health Institute, Basel, Switzerland

7. University of Basel, Basel, Switzerland

8. ISGlobal, Hospital Clínic-Universitat de Barcelona, Barcelona, Spain

9. Service of Infectious Diseases, Hospital del Mar Research Institute (IMIM), Hospital del Mar, Barcelona, Spain

Abstract

Over the past ten years, standard diagnostics for cryptococcal meningitis in HIV-infected persons have evolved from culture to India ink to detection of cryptococcal antigen (CrAg), with the recent development and distribution of a point-of-care lateral flow assay. This assay is highly sensitive and specific in cerebrospinal fluid (CSF), but is also sensitive in the blood to detect CrAg prior to meningitis symptoms.

Funder

NIAID

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Link

https://journals.asm.org/doi/pdf/10.1128/JCM.01238-18

Reference31 articles.

1. Global burden of disease of HIV-associated cryptococcal meningitis: an updated analysis

2. Detrimental Outcomes of Unmasking Cryptococcal Meningitis With Recent ART Initiation

3. HIV-Associated Cryptococcal Disease in Resource-Limited Settings: A Case for “Prevention Is Better Than Cure”?