Interleukin-8 gene expression in Staphylococcus aureus-infected endothelial cells

Author:

Yao L1,Lowy F D1,Berman J W1

Affiliation:

1. Department of Pathology, Albert Einstein College of Medicine, Bronx, New York 104611, USA.

Abstract

Interleukin-8 (IL-8) plays a crucial role in the migration of neutrophils to bacterium-infected sites. This study investigated IL-8 induction in Staphylococcus aureus-infected endothelial cells (EC). We observed that S. aureus-infected EC were induced to express both IL-8 mRNA and protein, which can promote transmigration of neutrophils across an EC monolayer.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Reference24 articles.

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5. Lipid A-like molecules that antagonize the effects of endotoxins on human monocytes;Golenbock D. T.;J. Biol. Chem.,1991

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