Impacts of L1 Promoter Variation and L2 Clavulanate Susceptibility on Ticarcillin-Clavulanate Susceptibility of Stenotrophomonas maltophilia-Reference-Cited by-同舟云学术

Impacts of L1 Promoter Variation and L2 Clavulanate Susceptibility on Ticarcillin-Clavulanate Susceptibility of Stenotrophomonas maltophilia

Published:2018-11 Issue:11 Volume:62 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Huang Hsin-Hui¹,Chen Peng-Ying¹,Hu Rouh-Mei²³,Lin Yi-Tsung⁴⁵,Li Li-Hua⁶⁷,Yang Tsuey-Ching¹

Affiliation:

1. Department of Biotechnology and Laboratory Science in Medicine, National Yang-Ming University, Taipei, Taiwan

2. Department of Bioinformatics and Medical Engineering, Asia University, Wufeng, Taichung, Taiwan

3. Department of Medical Research, China Medical University Hospital, Taichung, Taiwan

4. Division of Infectious Diseases, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan

5. School of Medicine, National Yang-Ming University, Taipei, Taiwan

6. Department of Pathology and Laboratory Medicine, Taipei Veterans General Hospital, Taipei, Taiwan

7. School of Medical Laboratory Science and Biotechnology, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan

Abstract

Inducible expression of L1 and L2 β-lactamases is the principal mechanism responsible for β-lactam resistance in Stenotrophomonas maltophilia . Ticarcillin-clavulanate (TIM) is one of the few effective β-lactams for S. maltophilia treatment.

Funder

Professor Tsuei-Chu Mong Merit Scholarship

Ministry of Science and Technology, Taiwan

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01222-18

Reference21 articles.

1. Three Decades of β-Lactamase Inhibitors

2. UREIDOPENICILLINS AND BETA-LACTAM/BETA-LACTAMASE INHIBITOR COMBINATIONS

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4. In vitro efficacy of β-lactam/β-lactamase inhibitor combinations against bacteria involved in mixed infections

5. Ceftazidime/Avibactam: A New Antibiotic for Gram-Negative Infections

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