Testing for Cytomegalovirus in Pregnancy-Reference-Cited by-同舟云学术

Testing for Cytomegalovirus in Pregnancy

Published:2017-03 Issue:3 Volume:55 Page:693-702
ISSN:0095-1137
Container-title:Journal of Clinical Microbiology
language:en
Short-container-title:J Clin Microbiol

Author:

Saldan Alda¹,Forner Gabriella¹,Mengoli Carlo¹,Gussetti Nadia²,Palù Giorgio¹,Abate Davide¹

Affiliation:

1. Department of Molecular Medicine, University of Padua, Padua, Italy

2. Padua Reference Center for Infections in Pregnancy, Padua General Hospital, Padua, Italy

Abstract

ABSTRACT Congenital cytomegalovirus (CMV) infection represents a relevant cause of deafness and neurological damage in newborns. Intrauterine CMV transmission might result after primary or nonprimary infections, though at different rates (30% versus 0.2%, respectively). At present, a prenatal diagnosis of CMV infection is based mainly on maternal serology, the detection of CMV-DNA in amniotic fluid and fetal blood, and ultrasound (US) and magnetic resonance imaging (MRI). Recent evidences suggest that congenital CMV infection may be an immune-mediated disease and that evaluation of humoral and especially T-cell immunities may improve the overall prenatal diagnosis. This review summarizes the most recent advancements in the diagnosis of maternal and prenatal CMV infections.

Funder

Università degli Studi di Padova

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Link

https://journals.asm.org/doi/pdf/10.1128/JCM.01868-16

Reference54 articles.

1. New estimates of the prevalence of neurological and sensory sequelae and mortality associated with congenital cytomegalovirus infection

2. Review and meta-analysis of the epidemiology of congenital cytomegalovirus (CMV) infection

3. Birth Prevalence and Natural History of Congenital Cytomegalovirus Infection in a Highly Seroimmune Population