Affiliation:
1. Division of Molecular Virology, Baylor College of Medicine, Houston, Texas 77030, USA.
Abstract
Two scientists who played leading roles in the conquest of poliomyelitis died recently. In 1954, Jonas Salk provided the first licensed polio vaccine, the formalin (and heat)-inactivated virus. Albert Sabin gave us the attenuated live virus vaccine, which was licensed in 1962. This paper takes the reader through the history of the disease, including its pathogenesis, epidemiology, vaccines, and future directions. The emphasis is on vaccines, for it seems that with proper vaccination the number of new cases is falling dramatically. It is hoped that by the year 2000, we will accomplish the goal of the World Health Organization of "a world without polio." Then, because there is no animal reservoir, we can seriously discuss when and how to eliminate the need for vaccination and ultimately destroy our stocks of poliovirus.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Microbiology (medical),Public Health, Environmental and Occupational Health,General Immunology and Microbiology,Epidemiology
Reference40 articles.
1. Neurovirulence test for oral live poliovaccines using poliovirus-sensitive transgenic mice;Abe S.;Virology,1995
2. The occurrence of poliomyelitis following tonsillectomy;Aycock W. L.;N. Engl. J. Med.,1929
3. Bodian D. and D. M. Horstmann. 1965. Polioviruses p. 430-473. In F. L. Horsfall and I. Tamm (ed.) Viral and rickettsial infections of Man 4th ed. J. B. Lippincott Co. Philadelphia.
4. Antigen chimeras of poliovirus;Burke K. L.;Prog. Med. Virol.,1991
5. Cabasso V. J. G. A. Jervis A. W. Moyer M. Roca-Garcia E. V. Orsi and H. R. Cox. 1959. Cumulative testing experience with consecutive lots of oral poliomyelitis vaccine p. 102-134. In Live poliovirus vaccines. Pan American Health Organization.
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