Affiliation:
1. Department of Pediatrics, State University of New York at Buffalo Medical School, and Laboratory of Bacteriology, Children's Hospital, Buffalo, New York
2. Department of Bacteriology, State University of New York at Buffalo Medical School, and Laboratory of Bacteriology, Children's Hospital, Buffalo, New York
Abstract
Domingue, Gerald
J. (State University of New York at Buffalo, Buffalo, N.Y.),
and Erwin Neter
. Opsonizing and bactericidal activity of antibodies against common antigen of
Enterobacteriaceae
. J. Bacteriol.
91:
129–133. 1966.—In addition to the well-known O, H, K, and Vi antigens,
Enterobacteriaceae
produce a common antigen, which was first identified by hemagglutination tests with
Escherichia coli
O14 antiserum. Studies on the biological significance of this antigen by in vitro phagocytic experiments have revealed that opsonization is markedly enhanced in the presence of the corresponding antibody, rabbit polymorphonuclear leukocytes, and normal rabbit serum. This effect is specific, because
Pseudomonas aeruginosa
, which is devoid of this antigen, is not opsonized under these conditions, and removal of the antibody by absorption markedly reduces the uptake of enteric bacteria containing the antigen. Opsonization thus represents another method for the study of this antigen-antibody system. Bactericidal tests have revealed that antibodies against this antigen, engendered in rabbits by different strains of enteric bacteria and various procedures, are bactericidal for
E. coli
O14 but not for other enteric bacteria, possibly due to previously demonstrated differences between the antigen moieties obtained from these microorganisms.
Publisher
American Society for Microbiology
Subject
Molecular Biology,Microbiology
Cited by
29 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献