Correlation of SARS-CoV-2 Nucleocapsid Antigen and RNA Concentrations in Nasopharyngeal Samples from Children and Adults Using an Ultrasensitive and Quantitative Antigen Assay-Reference-Cited by-同舟云学术

Correlation of SARS-CoV-2 Nucleocapsid Antigen and RNA Concentrations in Nasopharyngeal Samples from Children and Adults Using an Ultrasensitive and Quantitative Antigen Assay

Published:2021-03-19 Issue:4 Volume:59 Page:
ISSN:0095-1137
Container-title:Journal of Clinical Microbiology
language:en
Short-container-title:J Clin Microbiol

Author:

Pollock Nira R.¹^ORCID,Savage Timothy J.²,Wardell Hanna²,Lee Rose A.²,Mathew Anu³,Stengelin Martin³,Sigal George B.³

Affiliation:

1. Department of Laboratory Medicine, Boston Children’s Hospital, Boston, Massachusetts, USA

2. Division of Infectious Diseases, Department of Pediatrics, Boston Children’s Hospital, Boston, Massachusetts, USA

3. Meso Scale Diagnostics, LLC., Rockville, Maryland, USA

Abstract

Diagnosis of COVID-19 by PCR offers high sensitivity, but the utility of detecting samples with high cycle threshold ( C T ) values remains controversial. Currently available rapid diagnostic tests (RDTs) for SARS-CoV-2 nucleocapsid antigens (Ag) have sensitivity well below PCR.

Funder

Meso Scale Diagnostics

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Link

https://journals.asm.org/doi/pdf/10.1128/JCM.03077-20

Reference31 articles.

1. Center for Systems Science and Engineering. 2020. COVID-19 dashboard by the Center for Systems Science and Engineering (CCSE) at Johns Hopkins University (JHU). https://coronavirus.jhu.edu/map.html. Accessed 31 October 2020.

2. Centers for Disease Control. 2020. COVID data tracker. Centers for Disease Control and Prevention, Atlanta, GA. https://covid.cdc.gov/covid-data-tracker/#testing_testsperformed. Accessed 31 October 2020.

3. FDA. 2020. Package insert for the BD VeritorTM system for rapid detection of SARS-CoV-2. Food and Drug Administration, Washington, DC. https://www.fda.gov/media/139755/download. Accessed 2 November 2020.

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