Preparation of Decoquinate Solid Dispersion by Hot-Melt Extrusion as an Oral Dosage Form Targeting Liver-Stage Plasmodium Infection

Author:

Wang Hongxing123ORCID,Fan Yinzhou1,Qin Li2,Cheng Zhipeng2,Chen Xueqing1,Zeng Sumei1,Liang Shuanghong1,Tong Ying2,Tao Zhu2,Liu Yucheng2,Liu Xiaorong4,Ning Xiaohui1,Chen Peiquan2,Zhao Siting25,Chen Xiaoping25

Affiliation:

1. Division of Nanomedicine, Bluelight Pharmatech, Co., LTD, Guangzhou, China

2. CAS Lamvac Biotech Co., Guangzhou, China

3. Department of Biochemistry and Molecular Biology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

4. The Drug Discovery Pipeline, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China

5. Guangzhou Institute of Biomedicine and Health, Chinese Academy of Science, Guangzhou, China

Abstract

Liver-stage Plasmodium in humans is an early stage of malarial infection. Decoquinate (DQ) has a potent multistage antimalarial activity.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

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