Use of Xylitol To Enhance the Therapeutic Efficacy of Polymethylmethacrylate-Based Antibiotic Therapy in Treatment of Chronic Osteomyelitis

Author:

Beenken Karen E.,Bradney Laura,Bellamy William,Skinner Robert A.,McLaren Sandra G.,Gruenwald M. Johannes,Spencer Horace J.,Smith James K.,Haggard Warren O.,Smeltzer Mark S.

Abstract

ABSTRACTUsing a rabbit model of postsurgical osteomyelitis, we demonstrate that incorporation of xylitol into polymethylmethacrylate (PMMA) bone cement enhances the elution of daptomycin underin vivoconditions. We also demonstrate that this can be correlated with an improved therapeutic outcome in the treatment of a chronic bone infection following surgical debridement.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Reference21 articles.

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