Author:
Beenken Karen E.,Bradney Laura,Bellamy William,Skinner Robert A.,McLaren Sandra G.,Gruenwald M. Johannes,Spencer Horace J.,Smith James K.,Haggard Warren O.,Smeltzer Mark S.
Abstract
ABSTRACTUsing a rabbit model of postsurgical osteomyelitis, we demonstrate that incorporation of xylitol into polymethylmethacrylate (PMMA) bone cement enhances the elution of daptomycin underin vivoconditions. We also demonstrate that this can be correlated with an improved therapeutic outcome in the treatment of a chronic bone infection following surgical debridement.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
Cited by
18 articles.
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