In Vitro Activities of Doripenem and Six Comparator Drugs against 423 Aerobic and Anaerobic Bacterial Isolates from Infected Diabetic Foot Wounds-Reference-Cited by-同舟云学术

In Vitro Activities of Doripenem and Six Comparator Drugs against 423 Aerobic and Anaerobic Bacterial Isolates from Infected Diabetic Foot Wounds

Published:2008-02 Issue:2 Volume:52 Page:761-766
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Goldstein Ellie J. C.¹²,Citron Diane M.¹,Merriam C. Vreni¹,Warren Yumi A.¹,Tyrrell Kerin L.¹,Fernandez Helen T.¹

Affiliation:

1. R M Alden Research Laboratory, Santa Monica, California 90404

2. UCLA School of Medicine, Los Angeles, California 90095

Abstract

ABSTRACT Against 182 anaerobe and 241 aerobe strains obtained from diabetic foot infections, doripenem was the most active carbapenem against Pseudomonas aeruginosa (MIC 90 , 2 μg/ml), more active than imipenem against Proteus mirabilis , and ertapenem was more active against Escherichia coli and Klebsiella spp. The MIC 50 and MIC 90 values were ≤0.125 μg/ml for methicillin-sensitive Staphylococcus aureus and all streptococci and 0.25/1 for Bacteroides fragilis .

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01128-07

Reference19 articles.

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2. Anonymous. 2003. Doripenem: S 4661. Drugs R. D.4:363-365.

3. National diabetes fact sheet. 2005

4. Bacteriology of Moderate-to-Severe Diabetic Foot Infections and In Vitro Activity of Antimicrobial Agents

5. Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically; approved standard 2003

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