Pharmacodynamics of Doxycycline in a Murine Malaria Model-Reference-Cited by-同舟云学术

Pharmacodynamics of Doxycycline in a Murine Malaria Model

Published:2007-12 Issue:12 Volume:51 Page:4477-4479
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Batty Kevin T.¹,Law Angela S. F.¹,Stirling Verity²,Moore Brioni R.¹

Affiliation:

1. School of Pharmacy, Curtin University of Technology, Bentley, Western Australia

2. School of Medicine and Pharmacology, University of Western Australia, Crawley, Western Australia, Australia

Abstract

ABSTRACT Doxycycline is reported to impair second-generation parasite schizogony. The effects of doxycycline alone and combined with dihydroartemisinin were investigated in a murine malaria model. Doxycycline lowered the rate of parasite growth within 2 days, with maximum effect in 6 days. Addition of dihydroartemisinin led to an additive antimalarial effect.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00529-07

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