Pharmacokinetics of Ascending Doses of Praziquantel in Adults Infected with Opisthorchis felineus in Western Siberia, Russian Federation-Reference-Cited by-同舟云学术

Pharmacokinetics of Ascending Doses of Praziquantel in Adults Infected with Opisthorchis felineus in Western Siberia, Russian Federation

Published:2022-10-18 Issue:10 Volume:66 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Probst Alexandra¹²,Hofmann Daniela¹²,Fedorova Olga S.³,Mazeina Sofia V.³,Sokolova Tatiana S.³^ORCID,Golovach Ekaterina³,Keiser Jennifer¹²^ORCID

Affiliation:

1. Swiss Tropical and Public Health Institute, Allschwil, Switzerland

2. University of Basel, Basel, Switzerland

3. Siberian State Medical University, Tomsk, Russia

Abstract

Opisthorchiasis due to the liver fluke Opisthorchis felineus is highly prevalent in rural regions of Western Siberia, causing severe liver and bile duct maladies. Praziquantel administered as a three-dose regimen is the only drug used to treat O. felineus -infected individuals. A simpler single-dose treatment might serve as an alternative. The aim of this study was to compare the pharmacokinetic (PK) properties of single, ascending doses of praziquantel compared to multiple dosing in patients infected with O. felineus to contribute to updated treatment guidelines.

Funder

Swiss National Science Foundation

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/aac.00526-22

Reference32 articles.

1. Opisthorchis felineus, an emerging infection in Italy and its implication for the European Union

2. Emerging Foodborne Trematodiasis

3. Food-Borne Trematodiases

4. The zoonotic, fish-borne liver flukes Clonorchis sinensis, Opisthorchis felineus and Opisthorchis viverrini

5. Opisthorchis felineus infection and cholangiocarcinoma in the Russian Federation: A review of medical statistics