In Vitro Activity of Omadacycline, a New Tetracycline Analog, and Comparators against Clostridioides difficile-Reference-Cited by-同舟云学术

In Vitro Activity of Omadacycline, a New Tetracycline Analog, and Comparators against Clostridioides difficile

Published:2020-07-22 Issue:8 Volume:64 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Begum Khurshida¹,Bassères Eugénie¹,Miranda Julie¹,Lancaster Chris¹,Gonzales-Luna Anne J.¹,Carlson Travis J.²,Rashid Tasnuva¹,Eyre David W.³⁴,Wilcox Mark H.⁵⁶,Alam M. Jahangir¹,Garey Kevin W.¹^ORCID

Affiliation:

1. University of Houston College of Pharmacy, Houston, Texas, USA

2. Fred Wilson School of Pharmacy, High Point University, High Point, North Carolina, USA

3. Big Data Institute, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom

4. National Institute for Health Research Oxford Biomedical Research Centre, Oxford, United Kingdom

5. Healthcare Associated Infections Research Group, Leeds Institute for Medical Research, University of Leeds, Old Medical School, Leeds General Infirmary, Leeds, United Kingdom

6. Microbiology, Leeds Teaching Hospitals NHS Trust, Old Medical School, Leeds General Infirmary, Leeds, United Kingdom

Abstract

Omadacycline is a potent aminomethylcycline with in vitro activity against Gram-positive, Gram-negative, and anaerobic bacteria. Preliminary data demonstrated that omadacycline has in vitro activity against Clostridioides difficile ; however, large-scale in vitro studies have not been done. The purpose of this study was to assess the in vitro susceptibility of omadacycline and comparators on a large biobank of clinical C. difficile isolates.

Funder

Paratek Pharmaceuticals

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00522-20

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