Affiliation:
1. Department of Biochemistry, University of Leicester, England.
Abstract
Self-resistance has been investigated in Streptomyces caelestis (producer of the lincosamide antibiotic celesticetin), from which a lincosamide resistance determinant (clr) has been isolated on a 1-kilobase DNA fragment and cloned in Streptomyces lividans. The clr product is a specific methylase which produces a single residue of N6-monomethyladenine in 23S rRNA at position 2058, thereby rendering the 50S ribosmal subunit resistant to the action of lincosamides.
Publisher
American Society for Microbiology
Subject
Molecular Biology,Microbiology
Reference19 articles.
1. Macrolide resistance in Staphylococcus aureus: inducers of macrolide resistance;Allen N. E.;Antimicrob. Agents Chemother.,1977
2. Use of a fractionated coupled transcription-translation system in the study of ribosomal resistance mechanisms in antibiotic-producing Streptomyces;Calcutt M. J.;J. Gen. Microbiol.,1989
3. Translational attenuation: the regulation of bacterial resistance to the macrolide-lincosamide-streptogramin B antibiotics;Dubnau D.;Crit. Rev. Biochem.,1984
4. A family of r-determinants in Streptomyces spp. that specifies inducible resistance to macrolide, lincosamide, and streptogramin type B antibiotics;Fujisawa Y.;J. Bacteriol.,1981
5. Gale E. F. E. Cundliffe P. E. Reynolds M. H. Richmond and M. J. Waring. 1981. The molecular basis of antibiotic action 2nd ed. John Wiley & Sons Ltd. London.
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