Resistance to Replication of Human Immunodeficiency Virus Challenge in SCID-Hu Mice Engrafted with Peripheral Blood Mononuclear Cells of Nonprogressors Is Mediated by CD8 + T Cells and Associated with a Proliferative Response to p24 Antigen-Reference-Cited by-同舟云学术

Resistance to Replication of Human Immunodeficiency Virus Challenge in SCID-Hu Mice Engrafted with Peripheral Blood Mononuclear Cells of Nonprogressors Is Mediated by CD8 + T Cells and Associated with a Proliferative Response to p24 Antigen

Published:2000-02-15 Issue:4 Volume:74 Page:2023-2028
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

de Quiros Juan Carlos Lopez Bernaldo¹²,Shupert W. Lesley²,McNeil Andrew C.²,Gea-Banacloche Juan C.²,Flanigan Mark²,Savage Ann²,Martino Lisa²,Weiskopf Emma E.²,Imamichi Hiromi³,Zhang Yi-Ming³,Adelsburger Joseph³,Stevens Randy³,Murphy Philip M.⁴,Zimmerman Peter A.⁴,Hallahan Claire W.²,Davey Richard T.²,Connors Mark²

Affiliation:

1. Servicio de Medicina Interna 1, Clinica Puerta de Hierro, Universidad Autonoma de Madrid, and Servicio de Microbiologia, Hospital General Gregorio Maranon, Madrid, Spain,1 and

2. Laboratory of Immunoregulation2 and

3. SAIC/Frederick, Frederick Cancer Research and Development Center, Frederick,3 Maryland

4. Laboratory of Host Defense,4 National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, and

Abstract

ABSTRACT High levels of resistance to challenge with human immunodeficiency virus type 1 SF162 were observed in animals engrafted with peripheral blood mononuclear cells of four long-term nonprogressors (LTNPs). Resistance was abrogated by depletion of CD8 + T cells in vivo and was observed only in LTNPs with proliferative responses to p24. In a subgroup of nonprogressors, CD8 + T cells mediated restriction of challenge viruses, and this response was associated with strong proliferative responses to p24 antigen.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.74.4.2023-2028.2000

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