Inhibition of lymphocyte activation by hatching fluid from Schistosoma mansoni eggs

Author:

Wright E P,Guthrie C D,Salim D,Hilditch T J,Das P K

Abstract

A preparation of the fluid released upon hatching of the miracidia from Schistosoma mansoni eggs was found to have a potent inhibitory effect on the in vitro activation of hamster lymphocytes by mitogens. The effect was concentration dependent, not cytotoxic, and was the same on cells from healthy and schistosome-infected animals.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Reference14 articles.

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3. Immune responses during human schistosomiasis mansoni. IV. Induction of suppressor celi activity by schistosome antigen preparations and concanavalin A;Colley D. G.;J. Immunol.,1978

4. Immune responses during human schistosomiasis mansoni. VI. In vitro nonspecific suppression of phytohemagglutinin responsiveness induced by exposure to certain schistosomal preparations;Colley D. G.;J. Immunol.,1979

5. Inhibition of Iymphocyte activation by factor(s) produced by Schistosoma mansoni;Dessaint J. P.;Eur. J. Immunol.,1977

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