Affiliation:
1. Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.
Abstract
Analysis of the respiratory tract before and after primary influenza virus infection revealed a virus-induced preferential accumulation of a CD8+ T-cell population that coexpresses mRNA for interleukin-5 (IL-5) and IL-10 with virus dose-dependent high levels of gamma interferon. However, cytokine production in lung tissues was not restricted to the T-cell population, since CD3- cells were found to express mRNA for various cytokines, including IL-4 and particularly IL-6 and granulocyte-macrophage colony-stimulating factor. These data provide in vivo evidence for a local respiratory tract immune response to influenza virus infection dominated by cytokine-producing CD8+ T cells.
Publisher
American Society for Microbiology
Subject
Virology,Insect Science,Immunology,Microbiology
Reference29 articles.
1. The immune response to influenza infection;Ada G. L.;Curr. Top. Microbiol. Immunol.,1986
2. Cellular events in the Iymph node and Iung of mice with influenza. Consequences of depleting CD4+ T cells;Allan W.;J. Immunol.,1990
3. Recombinant murine IL-5 induces high rate IgA synthesis in cycling IgA-positive Peyer's patch B cells;Beagley K. W.;J. Immunol.,1988
4. Transgenic mice lacking class I major histocompatibility complexrestricted T cells have delayed viral clearance and increased mortality after influenza virus challenge;Bender B. S.;J. Exp. Med.,1992
5. Activation of cytokine genes in T cells during primary and secondary murine influenza pneumonia;Carding S. R.;J. Exp. Med.,1993
Cited by
95 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献