The Potential of Neuraminidase as an Antigen for Nasal Vaccines To Increase Cross-Protection against Influenza Viruses-Reference-Cited by-同舟云学术

The Potential of Neuraminidase as an Antigen for Nasal Vaccines To Increase Cross-Protection against Influenza Viruses

Published:2021-09-27 Issue:20 Volume:95 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Kawai Atsushi¹²³,Yamamoto Yasuyuki⁴,Nogimori Takuto⁵,Takeshita Kohei⁶,Yamamoto Takuya⁵,Yoshioka Yasuo¹²³⁴⁷

Affiliation:

1. Laboratory of Nano-design for Innovative Drug Development, Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka, Japan

2. Vaccine Creation Group, BIKEN Innovative Vaccine Research Alliance Laboratories, Institute for Open and Transdisciplinary Research Initiatives, Osaka University, Suita, Osaka, Japan

3. Vaccine Creation Group, BIKEN Innovative Vaccine Research Alliance Laboratories, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan

4. BIKEN Center for Innovative Vaccine Research and Development, The Research Foundation for Microbial Diseases of Osaka University, Suita, Osaka, Japan

5. Laboratory of Immunosenescence, National Institutes of Biomedical Innovation, Health and Nutrition, Ibaraki, Osaka, Japan

6. RIKEN SPring-8 Center, Sayo, Hyogo, Japan

7. Global Center for Medical Engineering and Informatics, Osaka University, Suita, Osaka, Japan

Abstract

Because mismatch between vaccine strains and epidemic strains cannot always be avoided, the development of influenza vaccines that induce broad cross-protection against antigenically mismatched heterologous strains is needed. Although the importance of NA-specific antibodies to cross-protection in humans and experimental animals is becoming clear, the potential of NA as an antigen for providing cross-protection through nasal vaccines is unknown.

Funder

Japan Agency for Medical Research and Development

MEXT | Japan Society for the Promotion of Science

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.01180-21

Reference72 articles.

1. Influenza

2. Advances in the development of influenza virus vaccines