Diversity of Dromedary Camel Coronavirus HKU23 in African Camels Revealed Multiple Recombination Events among Closely Related Betacoronaviruses of the Subgenus Embecovirus-Reference-Cited by-同舟云学术

Diversity of Dromedary Camel Coronavirus HKU23 in African Camels Revealed Multiple Recombination Events among Closely Related Betacoronaviruses of the Subgenus Embecovirus

Published:2019-12 Issue:23 Volume:93 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

So Ray T. Y.¹,Chu Daniel K. W.¹,Miguel Eve²,Perera Ranawaka A. P. M.¹,Oladipo Jamiu O.¹³,Fassi-Fihri Ouafaa⁴,Aylet Gelagay⁵,Ko Ronald L. W.¹,Zhou Ziqi¹,Cheng Mo-Sheung¹,Kuranga Sulyman A.³,Roger François L.⁶⁷,Chevalier Veronique⁶⁸,Webby Richard J.⁹,Woo Patrick C. Y.¹⁰^ORCID,Poon Leo L. M.¹,Peiris Malik¹^ORCID

Affiliation:

1. School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, Republic of China

2. MIVEGEC Maladies Infectieuses et Vecteurs: Ecologie, Génétique, Evolution et Contrôle, IRD L'Institut de Recherche pour le Développement, CNRS Centre National de Recherche Scientifique, Universitè de Montpellier, Montpellier, France

3. Department of Surgery, Faculty of Clinical Sciences, University of Ilorin, Ilorin, Nigeria

4. Institut Agronomique et Vétérinaire, Hassan II Université, Rabat, Morocco

5. Pan African Veterinary Center of the African Union (AU-PANVAC), Debre Zeit, Ethiopia

6. Animal, Santé, Territoires, Risques et Ecosystèmes, Centre de Coopération Internationale en Recherche Agronomique pour le Développement, Institut National de la Recherche Agronomique, Université de Montpellier, Montpellier, France

7. Kasetsart University, Bangkok, Thailand

8. Institut Pasteur du Cambodge, Phnom Penh, Cambodia

9. St. Jude Children’s Research Hospital, Memphis, Tennessee, USA

10. Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, Republic of China

Abstract

Genetic recombination is often demonstrated in coronaviruses and can result in host range expansion or alteration in tissue tropism. Here, we showed interspecies events of recombination of an endemic dromedary camel coronavirus, HKU23, with other clade A betacoronaviruses. Our results supported the possibility that the zoonotic pathogen MERS-CoV, which also cocirculates in the same camel species, may have undergone similar recombination events facilitating its emergence or may do so in its future evolution.

Funder

HHS | National Institutes of Health

University Grants Committee

Food and Health Bureau

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.01236-19

Reference49 articles.

1. Fatal swine acute diarrhoea syndrome caused by an HKU2-related coronavirus of bat origin