Long-Term Protective Effect of Serial Infections with H5N8 Highly Pathogenic Avian Influenza Virus in Wild Ducks

Author:

Caliendo Valentina1ORCID,Leijten Lonneke1,van de Bildt Marco W. G.1,Poen Marjolein J.1,Kok Adinda1,Bestebroer Theo1,Richard Mathilde1ORCID,Fouchier Ron A. M.1,Kuiken Thijs1

Affiliation:

1. Department of Viroscience, Erasmus University Medical Center, Rotterdam, The Netherlands

Abstract

This study showed that ducks infected with a less-virulent HPAIV developed immunity that was protective against a subsequent infection with a more-virulent HPAIV 9 months later. Following 2014 H5N8 infection, the proportion of birds with detectable influenza nucleoprotein antibody declined from 100% (8/8) in tufted ducks and 78% (7/9) in mallards after 1 month to 33% (2/6) in tufted ducks and 29% (2/7) in mallards after 9 months.

Funder

EC | Horizon 2020 Framework Programme

Division of Intramural Research, National Institute of Allergy and Infectious Diseases

HHS | NIH | National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

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