Affiliation:
1. Institut für Virologie der Universität Würzburg, D8700 Würzburg, Germany
Abstract
Evidence is presented that poliovirus particles with a single lethal hit by hydroxylamine do not induce in host cells either inhibition of cellular protein synthesis or viral ribonucleic acid (RNA) replication. The RNA of these viruses is not replicated even if the cells are simultaneously infected with both active and inactivated viruses. The damaged viral RNA seems to have lost both its template function and its function in the translation of normal viral proteins.
Publisher
American Society for Microbiology
Subject
Virology,Insect Science,Immunology,Microbiology
Reference30 articles.
1. Studies on the mechanism of poliovirus-induced cell damage. I. The relation between poliovirus-induced metabolic and morphological alterations in cultured cells;Bablanian R.;Virology,1965
2. Poliovirus-induced RNA polymerase and the effects of virus-specific inhibitors on its production;Baltimore D.;Proc. Nat. Acad. Sci. U.S.A.,1963
3. Mengovirus-induced inhibition of host ribonucleic acid and protein synthesis;Baltimore D.;Biochim. Biophys. Acta,1963
4. Replication of poliovirus RNA induced by heterologous virus;Cords C. E.;Proc. Nat. Acad. Sci. U.S.A.,1964
5. The RNA of influenza virus;Duesberg R.;Proc. Nat. Acad. Sci. U.S.A.,1952
Cited by
17 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献