Impact of Empirical-Therapy Selection on Outcomes of Intravenous Drug Users with Infective Endocarditis Caused by Methicillin-Susceptible Staphylococcus aureus-Reference-Cited by-同舟云学术

Impact of Empirical-Therapy Selection on Outcomes of Intravenous Drug Users with Infective Endocarditis Caused by Methicillin-Susceptible Staphylococcus aureus

Published:2007-10 Issue:10 Volume:51 Page:3731-3733
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Lodise Thomas P.¹,McKinnon Peggy S.²,Levine Donald P.³⁴,Rybak Michael J.³⁴⁵

Affiliation:

1. Albany College of Pharmacy, Albany, New York

2. Barnes-Jewish Hospital, St. Louis, Missouri

3. School of Medicine, Wayne State University, Detroit, Michigan

4. Detroit Receiving Hospital and University Health Center, Detroit, Michigan

5. Anti-Infective Laboratory, College of Pharmacy & Health Sciences, Wayne State University, Detroit, Michigan

Abstract

ABSTRACT This study compares beta-lactam and vancomycin among intravenous drug users with infective endocarditis caused by methicillin-susceptible Staphylococcus aureus . Patients who received vancomycin had higher infection-related mortality, even if they were switched to beta-lactam once culture results became available; this relationship persisted after logistic regression analysis controlling for clinical characteristics.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00101-07

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