Multicenter Evaluation of the Acuitas AMR Gene Panel for Detection of an Extended Panel of Antimicrobial Resistance Genes among Bacterial Isolates-Reference-Cited by-同舟云学术

Multicenter Evaluation of the Acuitas AMR Gene Panel for Detection of an Extended Panel of Antimicrobial Resistance Genes among Bacterial Isolates

Published:2022-03-16 Issue:3 Volume:60 Page:
ISSN:0095-1137
Container-title:Journal of Clinical Microbiology
language:en
Short-container-title:J Clin Microbiol

Author:

Simner Patricia J.¹^ORCID,Musser Kimberlee A.²^ORCID,Mitchell Kara²,Wise Mark G.³,Lewis Shawna¹,Yee Rebecca⁴,Bergman Yehudit¹,Good Caryn E.⁵,Abdelhamed Ayman M.⁵,Li Henry³,Laseman Erin M.³,Sahm Dan³,Pitzer Kelsey⁶,Quan Julia⁶,Walker G. Terrance⁶,Jacobs Michael R.⁵^ORCID,Rhoads Daniel D.⁷

Affiliation:

1. Johns Hopkins University School of Medicine, Baltimore, Maryland, USA

2. New York State Department of Health, Wadsworth Center, Albany, New York, USA

3. IHMA, Schaumburg, Illinois, USA

4. George Washington University School of Medicine and Health Sciences, Washington, DC, USA

5. University Hospitals Cleveland Medical Center, Cleveland, Ohio, USA

6. OpGen, Inc., Rockville, Maryland, USA

7. Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, Ohio, USA

Abstract

The Acuitas antimicrobial resistance (AMR) gene panel is a qualitative, multiplex, nucleic acid‐based in vitro diagnostic test for the detection and differentiation of 28 antimicrobial resistance markers associated with not susceptible results (NS; i.e., intermediate or resistant) to one or more antimicrobial agents among cultured isolates of select Enterobacterales , Pseudomonas aeruginosa , and Enterococcus faecalis . This study was conducted at four sites and included testing of 1,224 deidentified stocks created from 584 retrospectively collected isolates and 83 prospectively collected clinical isolates.

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Link

https://journals.asm.org/doi/pdf/10.1128/jcm.02098-21

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