Immunization with PspA Incorporated into a Poly(Ethylene Oxide) Matrix Elicits Protective Immunity against Streptococcus pneumoniae-Reference-Cited by-同舟云学术

Immunization with PspA Incorporated into a Poly(Ethylene Oxide) Matrix Elicits Protective Immunity against Streptococcus pneumoniae

Published:2007-06 Issue:6 Volume:14 Page:789-791
ISSN:1556-6811
Container-title:Clinical and Vaccine Immunology
language:en
Short-container-title:Clin Vaccine Immunol

Author:

Moore Quincy C.¹²³⁴,Johnson LaShundra¹²³⁴,Repka Michael¹²³⁴,McDaniel Larry S.¹²³⁴

Affiliation:

1. Departments of Microbiology

2. Surgery

3. Medicine, University of Mississippi Medical Center, Jackson, Mississippi 39216

4. Department of Pharmaceutics, The University of Mississippi, University, Mississippi 38677

Abstract

ABSTRACT CBA/N mice were immunized with PspA in a poly(ethylene oxide) matrix to examine its ability to deliver the antigen and modulate the immune response. All mice receiving PspA in the matrix survived a lethal pneumococcal challenge and had serum anti-PspA antibody levels statistically higher than mice receiving PspA alone ( P < 0.009).

Publisher

American Society for Microbiology

Subject

Microbiology (medical),Clinical Biochemistry,Immunology,Immunology and Allergy

Link

https://journals.asm.org/doi/pdf/10.1128/CVI.00082-07

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