Viral RNA-Dependent RNA Polymerase Inhibitor 7-Deaza-2′- C -Methyladenosine Prevents Death in a Mouse Model of West Nile Virus Infection-Reference-Cited by-同舟云学术

Viral RNA-Dependent RNA Polymerase Inhibitor 7-Deaza-2′- C -Methyladenosine Prevents Death in a Mouse Model of West Nile Virus Infection

Published:2019-03 Issue:3 Volume:63 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Eyer Luděk¹²,Fojtíková Martina¹,Nencka Radim³,Rudolf Ivo⁴⁵,Hubálek Zdeněk⁴⁵,Ruzek Daniel¹²^ORCID

Affiliation:

1. Department of Virology, Veterinary Research Institute, Brno, Czech Republic

2. Institute of Parasitology, Biology Centre of the Czech Academy of Sciences, Ceske Budejovice, Czech Republic

3. Institute of Organic Chemistry and Biochemistry, The Czech Academy of Sciences, Prague, Czech Republic

4. The Czech Academy of Sciences, Institute of Vertebrate Biology, Brno, Czech Republic

5. Masaryk University, Department of Experimental Biology, Brno, Czech Republic

Abstract

West Nile virus (WNV) is a medically important emerging arbovirus causing serious neuroinfections in humans and against which no approved antiviral therapy is currently available. In this study, we demonstrate that 2′- C -methyl- or 4′-azido-modified nucleosides are highly effective inhibitors of WNV replication, showing nanomolar or low micromolar anti-WNV activity and negligible cytotoxicity in cell culture.

Funder

Grantová Agentura České Republiky

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.02093-18

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