Emergence of OXA-48-Type Carbapenemase-Producing Enterobacteriaceae in German Hospitals-Reference-Cited by-同舟云学术

Emergence of OXA-48-Type Carbapenemase-Producing Enterobacteriaceae in German Hospitals

Published:2012-01-30 Issue:4 Volume:56 Page:2125-2128
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob. Agents Chemother.

Author:

Pfeifer Yvonne,Schlatterer Kathrin,Engelmann Elisabeth,Schiller Reinhold A.,Frangenberg Hans Reiner,Stiewe Doris,Holfelder Martin,Witte Wolfgang,Nordmann Patrice,Poirel Laurent

Abstract

ABSTRACTNine carbapenem-resistantEnterobacteriaceaeisolates collected from eight patients in five German hospitals were investigated. Six isolates produced the OXA-48 carbapenemase, and three isolates produced OXA-162, which is a point mutant form of OXA-48. Both carbapenemase genes were located on IncL/M-type conjugative plasmids. Insertion sequence IS1999(truncated or not by IS1R) was located upstream of theblaOXA-48andblaOXA-162genes in all of the isolates. Pulsed-field gel electrophoresis typing indicated the clonal transmission of an OXA-48-producingKlebsiella pneumoniaestrain in two hospitals.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

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