Affiliation:
1. Department of Microbiology, University of Massachusetts, Amherst, Massachusetts 01002
Abstract
Virulent
Treponema pallidum
has been shown to consume O
2
at a rate similar to that of the known aerobic spirochaete,
Leptospira.
Such O
2
uptake is cyanide sensitive, indicating a functioning cytochrome oxidase. Inhibition of O
2
uptake by azide, chlorpromazine, and amytal further suggests a functioning electron transport system for the oxidation of nicotinamide adenine dinucleotide (reduced) to O
2
. Evidence is consistent with the probability that this terminal electron-transport system is coupled to oxidative phosphorylation. The potential significance of these findings is discussed.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Immunology,Microbiology,Parasitology
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