Pulmonary Mycobacterium bovis BCG Vaccination Confers Dose-Dependent Superior Protection Compared to That of Subcutaneous Vaccination-Reference-Cited by-同舟云学术

Pulmonary Mycobacterium bovis BCG Vaccination Confers Dose-Dependent Superior Protection Compared to That of Subcutaneous Vaccination

Published:2014-04 Issue:4 Volume:21 Page:594-597
ISSN:1556-6811
Container-title:Clinical and Vaccine Immunology
language:en
Short-container-title:Clin Vaccine Immunol

Author:

Aguilo Nacho¹²,Toledo Ana Maria³,Lopez-Roman Eva Maria³,Perez-Herran Esther³,Gormley Eamonn⁴,Rullas-Trincado Joaquin³,Angulo-Barturen Iñigo³,Martin Carlos¹²⁵

Affiliation:

1. Grupo de Genética de Micobacterias, Departmento de Microbiología, Medicina Preventiva y Salud Pública, Faculty of Medicine, Universidad de Zaragoza, Zaragoza, Spain

2. CIBER Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain

3. Diseases of the Developing World, GlaxoSmithKline, Tres Cantos, Madrid, Spain

4. School of Veterinary Medicine, University College Dublin (UCD), Dublin, Ireland

5. Servicio de Microbiología, Hospital Universitario Miguel Servet, IIS Aragón, Zaragoza, Spain

Abstract

ABSTRACT Worldwide, the Mycobacterium bovis BCG vaccine is one of the most widely used vaccines. However, it appears to be ineffective in preventing pulmonary tuberculosis. Here, we show that pulmonary BCG vaccination of mice with a broad dose range provides superior protection against Mycobacterium tuberculosis challenge compared to that of subcutaneous vaccination.

Publisher

American Society for Microbiology

Subject

Microbiology (medical),Clinical Biochemistry,Immunology,Immunology and Allergy

Link

https://journals.asm.org/doi/pdf/10.1128/CVI.00700-13

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