Gastric Metabolomics Detects Helicobacter pylori Correlated Loss of Numerous Metabolites in Both the Corpus and Antrum-Reference-Cited by-同舟云学术

Gastric Metabolomics Detects Helicobacter pylori Correlated Loss of Numerous Metabolites in Both the Corpus and Antrum

Published:2021-01-19 Issue:2 Volume:89 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Keilberg Daniela¹^ORCID,Steele Nina²^ORCID,Fan Sili³^ORCID,Yang Christina¹^ORCID,Zavros Yana²,Ottemann Karen M.¹^ORCID

Affiliation:

1. Department of Microbiology and Environmental Toxicology, University of California, Santa Cruz, California, USA

2. Department of Pathology and Lab Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA

3. West Coast Metabolomics Center, University of California Davis, Davis, California, USA

Abstract

Helicobacter pylori is a chronic bacterial pathogen that thrives in several regions of the stomach, causing inflammation that can vary by site and result in distinct disease outcomes. Whether the regions differ in terms of host-derived metabolites is not known. We thus characterized the regional variation of the metabolomes of mouse gastric corpus and antrum organoids and tissue. The uninfected secreted organoid metabolites differed between the corpus and antrum in only seven metabolites as follows: lactic acid, malic acid, phosphoethanolamine, alanine, uridine, glycerol, and isoleucine.

Funder

California Cancer Research Coordinating Committee

HHS | NIH | National Institute of Allergy and Infectious Diseases

HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases

Deutsche Akademie der Naturforscher Leopoldina - Nationale Akademie der Wissenschaften

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.00690-20

Reference53 articles.