Intrapulmonary Treatment with Mycobacteriophage LysB Rapidly Reduces Mycobacterium abscessus Burden-Reference-Cited by-同舟云学术

Intrapulmonary Treatment with Mycobacteriophage LysB Rapidly Reduces Mycobacterium abscessus Burden

Published:2023-06-15 Issue:6 Volume:67 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Hurst-Hess Kelley¹,Walz Amanda²,Yang Yong¹³,McGuirk Helen³,Gonzalez-Juarrero Mercedes²,Hatfull Graham F.⁴^ORCID,Ghosh Pallavi¹⁵^ORCID,Ojha Anil K.¹⁵^ORCID

Affiliation:

1. Division of Genetics, Wadsworth Center, New York State Department of Health, Albany, New York, USA

2. Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, Colorado, USA

3. Department of Infectious Diseases and Microbiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA

4. Department of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania, USA

5. Department of Biomedical Sciences, University at Albany, Albany, New York, USA

Abstract

Intrinsic and acquired antibiotic resistance in Mycobacterium abscessus presents challenges in infection control, and new therapeutic strategies are needed. Bacteriophage therapy shows promise, but variabilities in M. abscessus phage susceptibility limits its broader utility.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

HHS | NIH | National Institute of General Medical Sciences

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/aac.00162-23

Reference18 articles.

1. Mycobacterium abscessus: a new antibiotic nightmare

2. Nontuberculous Mycobacteria

3. Management of Multidrug Resistant Infections in Lung Transplant Recipients with Cystic Fibrosis

4. Phage Therapy of Mycobacterium Infections: Compassionate Use of Phages in 20 Patients With Drug-Resistant Mycobacterial Disease

5. Engineered bacteriophages for treatment of a patient with a disseminated drug-resistant Mycobacterium abscessus

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