Antileishmanial Effects of Synthetic Eh PIb Analogs Derived from the Entamoeba histolytica Lipopeptidephosphoglycan-Reference-Cited by-同舟云学术

Antileishmanial Effects of Synthetic Eh PIb Analogs Derived from the Entamoeba histolytica Lipopeptidephosphoglycan

Published:2020-06-23 Issue:7 Volume:64 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Fehling Helena¹,Choy Siew Ling¹,Ting Frederic²,Landschulze Dirk²,Bernin Hannah¹,Lender Sarah Corinna¹,Mühlenpfordt Melina¹,Bifeld Eugenia³,Eick Julia³,Marggraff Claudia¹,Kottmayr Nadine¹,Groneberg Marie¹,Hoenow Stefan¹,Sellau Julie¹,Clos Joachim³^ORCID,Meier Chris²,Lotter Hannelore¹

Affiliation:

1. Department of Molecular Parasitology and Immunology, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany

2. Department of Chemistry, University of Hamburg, Hamburg, Germany

3. Leishmaniasis Group, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany

Abstract

With an estimated number of new cases annually of approximately 1.4 million, leishmaniasis belongs to the most important parasitic diseases in the world. Nevertheless, existing drugs against leishmaniasis in general have several drawbacks that urgently necessitate new drug development. A glycolipid molecule of the intestinal protozoan parasite Entamoeba histolytica and its synthetic analogs previously showed considerable immunotherapeutic effects against Leishmania major infection.

Funder

Werner Otto Stiftung

German Center for Infection Research

Leibniz Graduate School

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00161-20

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