Tigecycline Potentiates Clarithromycin Activity against Mycobacterium avium In Vitro-Reference-Cited by-同舟云学术

Tigecycline Potentiates Clarithromycin Activity against Mycobacterium avium In Vitro

Published:2016-04 Issue:4 Volume:60 Page:2577-2579
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Bax Hannelore I.¹,Bakker-Woudenberg Irma A. J. M.²,ten Kate Marian T.²,Verbon Annelies¹²,de Steenwinkel Jurriaan E. M.²

Affiliation:

1. Department of Internal Medicine, Section of Infectious Diseases, Erasmus University Medical Centre, Rotterdam, The Netherlands

2. Department of Medical Microbiology and Infectious Diseases, Erasmus University Medical Centre, Rotterdam, The Netherlands

Abstract

ABSTRACT The in vitro activities of clarithromycin and tigecycline alone and in combination against Mycobacterium avium were assessed. The activity of clarithromycin was time dependent, highly variable, and often resulted in clarithromycin resistance. Tigecycline showed concentration-dependent activity, and mycobacterial killing could only be achieved at high concentrations. Tigecycline enhanced clarithromycin activity against M. avium and prevented clarithromycin resistance. Whether there is clinical usefulness of tigecycline in the treatment of M. avium infections needs further study.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.02864-15

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