The complement control protein homolog of herpesvirus saimiri regulates serum complement by inhibiting C3 convertase activity-Reference-Cited by-同舟云学术

The complement control protein homolog of herpesvirus saimiri regulates serum complement by inhibiting C3 convertase activity

Published:1995-06 Issue:6 Volume:69 Page:3889-3892
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Fodor W L¹,Rollins S A¹,Bianco-Caron S¹,Rother R P¹,Guilmette E R¹,Burton W V¹,Albrecht J C¹,Fleckenstein B¹,Squinto S P¹

Affiliation:

1. Alexion Pharmaceuticals Inc., New Haven, Connecticut 06511, USA.

Abstract

The herpesvirus saimiri genome encodes a complement control protein homolog (CCPH). Stable mammalian cell transfectants expressing a recombinant transmembrane form of CCPH (mCCPH) or a 5'FLAG epitope-tagged mCCPH (5'FLAGmCCPH) conferred resistance to complement-mediated cell damage by inhibiting the lytic activity of human serum complement. The function of CCPH was further defined by showing that the mCCPH and the 5'FLAGmCCPH transfectants inhibited C3 convertase activity and effectively reduced cell surface deposition of the activated complement component, C3d.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jvi.69.6.3889-3892.1995

Reference23 articles.

1. New member of the multigene family of complement control proteins in herpesvirus saimiri;Albrecht J.;J. Virol.,1992

2. Primary structure of the herpesvirus saimiri genome;Albrecht J.;J. Virol.,1992

3. Herpesvirus saimiri has a gene specifying a homologue of the cellular membrane glycoprotein CD59;Albrecht J.;Virology,1992

4. Ausubel F. M. R. Brent R. E. Kingston D. D. Moore J. G. Seidman J. A. Smith and K. Struhl (ed.). 1991. Current protocols in molecular biology vol. 1. John Wiley & Sons. New York.

5. Cloning of decay-accelerating factor suggests novel use of splicing to generate two proteins;Caras I. W.;Nature (London),1987

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