Restrictions to the Adaptation of Influenza A Virus H5 Hemagglutinin to the Human Host-Reference-Cited by-同舟云学术

Restrictions to the Adaptation of Influenza A Virus H5 Hemagglutinin to the Human Host

Published:2004-01 Issue:1 Volume:78 Page:502-507
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Harvey Ruth¹²,Martin Andrew C. R.¹,Zambon Maria²,Barclay Wendy S.¹

Affiliation:

1. School of Animal and Microbial Sciences, University of Reading, Reading RG6 6AJ

2. Health Protection Agency, Enteric and Respiratory Virus Laboratory, Colindale, London NW9 5HT, United Kingdom

Abstract

ABSTRACT The binding specificities of a panel of avian influenza virus subtype H5 hemagglutinin (HA) proteins bearing mutations at key residues in the receptor binding site were investigated. The results demonstrate that two simultaneous mutations in the receptor binding site resulted in H5 HA binding in a pattern similar to that shown by human viruses. Coexpression of the ion channel protein, M2, from most avian and human strains tested protected H5 HA conformation during trafficking, indicating that no genetic barrier to the reassortment of the H5 surface antigen gene with internal genes of human viruses existed at this level.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.78.1.502-507.2004

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