Expression of the Mouse Hepatitis Virus Receptor by Central Nervous System Microglia-Reference-Cited by-同舟云学术

Expression of the Mouse Hepatitis Virus Receptor by Central Nervous System Microglia

Published:2004-07-15 Issue:14 Volume:78 Page:7828-7832
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Ramakrishna Chandran¹²,Bergmann Cornelia C.¹²,Holmes Kathryn V.³,Stohlman Stephen A.¹²⁴

Affiliation:

1. Departments of Neurology

2. Pathology

3. Department of Microbiology, University of Colorado Health Science Center, Denver, Colorado 80262

4. Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, California 90033

Abstract

ABSTRACT Detection of the mouse hepatitis virus receptor within the central nervous system (CNS) has been elusive. Receptor expression on microglia was reduced during acute infection and restored following immune-mediated virus control. Receptor down regulation was independent of neutrophils, NK cells, gamma interferon, or perforin. Infection of mice devoid of distinct inflammatory cells revealed CD4 + T cells as the major cell type influencing receptor expression by microglia. In addition to demonstrating receptor expression on CNS resident cells, these data suggest that transient receptor down regulation on microglia aids in establishing persistence in the CNS by assisting virus infection of other glial cell types.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.78.14.7828-7832.2004

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