Lentiviral Transduction of Dendritic Cells Confers Protective Antiviral Immunity In Vivo-Reference-Cited by-同舟云学术

Lentiviral Transduction of Dendritic Cells Confers Protective Antiviral Immunity In Vivo

Published:2004-07-15 Issue:14 Volume:78 Page:7843-7845
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Zarei Shohreh¹,Abraham Shahnaz²,Arrighi Jean-Francois²,Haller Olivier¹,Calzascia Thomas³,Walker Paul R.³,Kündig Thomas M.⁴,Hauser Conrad¹²,Piguet Vincent²

Affiliation:

1. Department of Immunology and Allergy

2. Department of Dermatology and Venereology

3. Department of Oncology, University Hospital of Geneva, Geneva

4. Dermatology Clinic, Zürich University Hospital, Zürich, Switzerland

Abstract

ABSTRACT Control of a viral infection in vivo requires a rapid and efficient cytotoxic-T-lymphocyte response. We demonstrate that lentivirus-mediated introduction of antigen in dendritic cells confers a protective antiviral immunity in vivo in a lymphocytic choriomeningitis virus model. Therefore, lentiviral vectors may be excellent vaccine candidates for viral infections.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.78.14.7843-7845.2004

Reference21 articles.

1. Immune therapy of a persistent and disseminated viral infection

2. Bachmann, M. F., T. M. Kundig, H. Hengartner, and R. M. Zinkernagel. 1997. Protection against immunopathological consequences of a viral infection by activated but not resting cytotoxic T cells: T cell memory without “memory T cells”? Proc. Natl. Acad. Sci. USA94:640-645.

3. Battegay, M., S. Cooper, A. Althage, J. Banziger, H. Hengartner, and R. M. Zinkernagel. 1991. Quantification of lymphocytic choriomeningitis virus with an immunological focus assay in 24- or 96-well plates. J. Virol. Methods33:191-198. (Errata, 35:115, 1991, and 38:263, 1992.)

4. Dyall, J., J. B. Latouche, S. Schnell, and M. Sadelain. 2001. Lentivirus-transduced human monocyte-derived dendritic cells efficiently stimulate antigen-specific cytotoxic T lymphocytes. Blood97:114-121.

5. Esslinger, C., L. Chapatte, D. Finke, I. Miconnet, P. Guillaume, F. Levy, and H. R. MacDonald. 2003. In vivo administration of a lentiviral vaccine targets DCs and induces efficient CD8+ T cell responses. J. Clin. Investig.111:1673-1681.

Cited by 26 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Nano-vaccines for gene delivery against HIV-1 infection;Expert Review of Vaccines;2023-03-29

2. Modulation of immune responses in lentiviral vector-mediated gene transfer;Cellular Immunology;2019-08

3. Alarmin augments the antitumor immunity of lentiviral vaccine in ectopic, orthotopic and autochthonous hepatocellular carcinoma mice;Theranostics;2019

4. Immune responses in liver-directed lentiviral gene therapy;Translational Research;2013-04

5. Virus-Receptor Mediated Transduction of Dendritic Cells by Lentiviruses Enveloped with Glycoproteins Derived from Semliki Forest Virus;PLoS ONE;2011-06-27