Postattachment Events Associated with Viral Entry Are Necessary for Induction of Interferon-Stimulated Genes by Human Cytomegalovirus-Reference-Cited by-同舟云学术

Postattachment Events Associated with Viral Entry Are Necessary for Induction of Interferon-Stimulated Genes by Human Cytomegalovirus

Published:2004-06-15 Issue:12 Volume:78 Page:6688-6691
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Netterwald James R.¹,Jones Thomas R.¹,Britt William J.²,Yang Shao-Jun¹,McCrone Ian P.¹,Zhu Hua¹

Affiliation:

1. Department of Microbiology and Molecular Genetics, UMDNJ-New Jersey Medical School, Newark, New Jersey 07103

2. Department of Pediatrics, Microbiology and Neurobiology, University of Alabama at Birmingham, Birmingham, Alabama 35233

Abstract

ABSTRACT Utilizing a human cytomegalovirus-specific fusion inhibitor and an antiglycoprotein H antibody, we studied the role of virion fusion in interferon-stimulated gene (ISG) induction. Our results indicate that ISG induction does not occur when virion-mediated, post-high-affinity attachment events are inhibited by either reagent. Thus, virion-mediated postattachment events, such as fusion, are required for ISG induction.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.78.12.6688-6691.2004

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